Free nerve endings, and receptor laden nerve fibers of small DRG’s discharge upon axonal crush, or tissue swelling. Histamine release produces long term pain axon stimulation. The pain pathway neurons are small dorsal root ganglion cells that give rise to slow conducting C fibers. These axons are unmyelinated and lightly myelinated and project into the dorsal lateral fasciculus. Those small DRG’s with touch endings such as dome endings, hair follicle receptors, Meisners and temperature endings (Kraus & Ruffini end bulbs) define a general area of activation and are transmitted on the pain path contralaterally as the axons ascend to VPL/VPM of dorsal thalamus.

Free nerve endings, and receptor laden nerve fibers of small DRG’s discharge upon axonal crush, or tissue swelling. Histamine release produces long term pain axon stimulation. The pain pathway neurons are small dorsal root ganglion cells that give rise to slow conducting C fibers. These axons are unmyelinated and lightly myelinated and project into the dorsal lateral fasciculus. Those small DRG’s with touch endings such as dome endings, hair follicle receptors, Meisners and temperature endings (Kraus & Ruffini end bulbs) define a general area of activation and are transmitted on the pain path contralaterally as the axons ascend to VPL/VPM of dorsal thalamus.
Pain is recognized in the sensory thalamus but localized in the sensory cortex.
ALS (Lateral spinothalamic)-

Pain is recognized in the sensory thalamus but localized in the sensory cortex.